D-Net has been entrusted by a wide range of clients ranging from UN, international NGOs, national NGOs, universities to the government ministries and departments. It has also been entrusted by other international institutions and universities, agencies from UK, Sweden and the Netherlands. Followings are the major clients of the firm:
| Type of organizations | Nepal | Overseas |
UN organizations | UNICEF | |
| WHO | ||
| ILO | ||
| UNFPA | ||
INGOs | CARE International | Belgium Red Cross |
| Lutheran World Federation (LWF) | Danish Red Cross | |
| Plan Nepal | Swiss Red Cross | |
| International Development Enterprise (IDE) | ||
| Save the Children/USA | ||
| Practical Action Nepal | ||
NGOs | Nepal Red Cross Society (NRCS) | |
| Family Planning Association of Nepal | ||
| ENPHO | ||
| NSET Nepal | ||
| SOPHEN | ||
Academics | Kathmandu University (KU) | University of Kalmar, LAQUA group , Sweden |
| Water and Engineering Development Center (WEDC)/Loughborough University, UK | ||
| IHE Delft, Netherlands | ||
Government and local government bodies | Department Water Supply and Sewerage (DWSS) | |
| Ministry of Environment, Science and Technology (MOEST) and earlier MOPE | ||
| Solid waste Management and Resource Mobilization Center (SWM&RMC) | ||
| Bharatpur municipality | ||
| Kathmandu Metropolitan City (KMC) | ||
Others/Research Organizations | Alternative Energy Promotion Center (AEPC) | International Foundation for Science (IFS), Sweden |
| Asian Development Bank (ADB) | Bangladesh Center for Advanced Studies (BCAS) | |
| World Bank (WB) |